Current Issue : January - March Volume : 2019 Issue Number : 1 Articles : 5 Articles
As skin ages, there is a decline in physiologic function. These changes are induced by\nboth intrinsic (chronologic) and extrinsic (predominately UV-induced) factors. Botanicals offer\npotential benefits to combat some of the signs of aging. Here, we review select botanicals and the\nscientific evidence behind their anti-aging claims. Botanicals may offer anti-inflammatory, antioxidant,\nmoisturizing, UV-protective, and other effects. A multitude of botanicals are listed as ingredients in\npopular cosmetics and cosmeceuticals, but only a select few are discussed here. These were chosen\nbased on the availability of scientific data, personal interest of the authors, and perceived â??popularityâ?\nof current cosmetic and cosmeceutical products. The botanicals reviewed here include argan oil,\ncoconut oil, crocin, feverfew, green tea, marigold, pomegranate, and soy....
Skin aging is a complex process which involves all the layers of the epidermis and dermis.\nIn order to slow skin aging, methods are researched which would strengthen and protect skin\nstem cells. Science is in search of the right method to stimulate the proliferation of epidermal stem\ncells. Plant stem cells show outstanding anti-aging properties, as they can, among other activities,\nstimulate fibroblasts to synthesise collagen, which, in turn, stimulates skin regeneration. One of\nthe most important agents which give anti-aging properties to plant stem cell extracts is kinetin\n(6-furfuryladenine). This compound belongs to a cytokine group and is considered to be a strong\nantioxidant which protects protein and nucleic acids from oxidation and glycoxidation processes.\nIt enables cells to remove the excess of free radicals to protect them from oxidative stress....
Bioactive ingredients from natural sources possess well-known positive effects in\ncosmetic applications. Among them, phenolic acids have emerged with very interesting potential.\nCaffeic acid (CAF) is one of the most promising active compounds because it possess antioxidant,\nanti-inflammatory, antitumoral and anti-wrinkle effects. In order to increase its local bioavailability\nin topical applications, the vehiculation of caffeic acid can lead to a new raw material of cosmetic\ninterest. For this purpose, clay minerals possess excellent properties, such as low or null toxicity\nand good biocompatibility. Clays are able to host a wide range of active ingredients in the interlayer\nregion, using a green process known as intercalation reaction. The hosting of cosmetic actives\ninto the layered structure of anionic clays allows the preparation of new materials with enhanced\nstability towards oxidation and photodegradation, better local bioavailability, and easier workability.\nIn this paper, the successful vehiculation of caffeic acid into anionic clay is presented. The obtained\nhybrid is very promising for the cosmetic market because of its higher bioavailability and prolonged\nantioxidant activity....
1) Background: Açai berry extract is known for its high content in polyphenols and thus is\na promising ingredient for cosmetic antiaging formulations; (2) Methods: In this study, the açai extract\nwas firstly evaluated for its total phenol content (Folin Ciocalteau essay) and antioxidant activity\n(radical scavenging activityâ??DPPH; radical cation scavenging capacityâ??ABTS; ferric reducing\nantioxidant capacityâ??FRAP). Next, the açai extract was included in an O/W formulation and again\nwas evaluated for its polyphenol content and antioxidant capacity. The formulation was tested for\ngeneral characteristics, physicochemical properties and microbial stability. The proliferative effect\non human immortalized fibroblasts was evaluated by the MTT essay, while TAC assay served to\nconfirm that fibroblasts are protected from UV irradiation. The irritant potential was verified on\n20 volunteers. The study concluded with the assessment of the sensorial characteristics of the cosmetic\nformulation; (3) Results: The pure açai extract exhibited high polyphenol content and antioxidant\nactivity, and these characteristics were preserved in the O/W formulation as well. The O/W cosmetic\nformulation proved to be stable under accelerated and normal conditions, and the preservatives\nwere successful in challenging the resistance against microbial contamination. The mean irritant\npotential was zero in all volunteers, and the cosmetic formulation showed a good sensorial profile;\n(4) Conclusions: Açai extract is an interesting ingredient for cosmetic antiaging formulations....
This study aimed to encapsulate Celastrus paniculatus seed oil (CPSO) in 2-hydroxypropyl ..-cyclodextrin ..... cavities and investigate their biological activity, physicochemical stability,\nand skin penetration by vertical Franz diffusion cells of the CPSO-HP ... inclusion complex\nformulations. For biological activity studiesâ??including 2,2-diphenyl-1-picryhydrazyl radical (DPPH)\nscavenging, metal ion chelating, and inhibition of lipid and tyrosinase inhibition activitiesâ??the\nCPSO-HP .... inclusion complex exhibited lower inhibition activity than free CPSO. CPSO-HP ... dispersion, serum, and gel formulations were prepared. All formulations containing the\nCPSO ... inclusion complex showed no significant changes in physical characteristics after three\nmonthsâ?? storage. The percentages of oleic acid remaining in all formulations were over 80% of the\ninitial amount during a three-month stability study. For the skin-penetration study, compared to other\nformulations, the CPSO-HP ... serum formulation exhibited the highest cumulative amount of oleic\nacid in the whole skin and flux through receptor fluid, after six hours, of 32.75 ± 1.25 ...... and ..... respectively. The CPSO-HP .... serum formulation also showed the proper\nviscosity. Hence, the CPSO-HP .... inclusion complex will be beneficial for the further development\nof cosmeceutical products....
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